@article{
	11589_70521,
	author = { De Marinis  Dario  and  De Tullio  Marco Donato  and  Napolitano  Michele  and  Pascazio  Giuseppe },
	title = {Improving a conjugate-heat-transfer immersed-boundary method},
	year = {2016},
	journal = {INTERNATIONAL JOURNAL OF NUMERICAL METHODS FOR HEAT & FLUID FLOW},
	volume = {26},
	keywords = {Conjugate heat transfer; Immersed boundary method; URANS; Mechanical Engineering; Mechanics of Materials; Computer Science Applications1707 Computer Vision and Pattern Recognition; Applied Mathematics},
	url = {http://www.emeraldinsight.com/info/journals/hff/hff.jsp},
	doi = {10.1108/HFF-11-2015-0473},	
	pages = {1272--1288}
}
@article{
	11589_73850,
	author = { Coclite  Alessandro  and  de Tullio  Marco Donato  and  Pascazio  Giuseppe  and  Decuzzi  Paolo },
	title = {A combined Lattice Boltzmann and Immersed boundary approach for predicting the vascular transport of differently shaped particles},
	year = {2016},
	journal = {COMPUTERS & FLUIDS},
	volume = {136},
	keywords = {Immersed boundary; Lattice-Boltzmann; Neutrally buoyant particle; Particle transport; Shear flow; Computer Science (all); Engineering (all)},
	doi = {10.1016/j.compfluid.2016.06.014},	
	pages = {260--271}
}
@article{
	11589_56097,
	author = { Doronzo  Domenico M  and  de Tullio  Marco D  and  Pascazio  Giuseppe  and  Dellino  Pierfrancesco  and  Liu  Guilin },
	title = {On the interaction between shear dusty currents and buildings in vertical collapse: Theoretical aspects, experimental observations, and 3D numerical simulation},
	year = {2015},
	journal = {JOURNAL OF VOLCANOLOGY AND GEOTHERMAL RESEARCH},
	volume = {302},
	abstract = {We investigate the behavior of vertical building collapses that, at impact on the ground, can generate shear dusty currents. These currents macroscopically resemble natural currents like dust storms and pyroclastic density currents, which may heavily interact with the surroundings while propagating. In particular, shear dusty currents are generated because of building collapse after pulverization, whereas pyroclastic density currents can be generated because of eruptive column or volcano collapse after fragmentation. Pyroclastic density currents can move for kilometers, and then load the surroundings by flow dynamic pressure; a similar dynamical behavior occurs in shear dusty currents that load buildings. We employed 3D engineering fluid dynamics to simulate the generation (by vertical collapse), and the propagation and building interaction of shear dusty currents. We used an Eulerian-Lagrangian multiphase approach to model the gas-particle flow, and an immersed boundary technique to mesh the domain, in order to account for sedimentary processes and complex 3D urban geometry in the computation. Results show that the local dynamic pressure of the shear current is amplified up to a factor ~. 10 because of flow-building interaction. Also, the surroundings consisting of multiple buildings and empty spaces make walls and streets as surfaces of particle accumulation, which from the collapse zone on can get thinner by exponential law. These results can help better assessing the intricate interaction between pyroclastic density currents and urban surroundings, as well as better link fragmentation, collapse and density current to each other.},
	keywords = {Dynamic pressure; Flow-building interaction; Fragmentation; Particle accumulation; Pyroclastic density currents; Shear dusty current; Geochemistry and Petrology; Geophysics},
	url = {http://www.sciencedirect.com/science/journal/03770273},
	doi = {10.1016/j.jvolgeores.2015.07.011},	
	pages = {190--198}
}
@article{
	11589_57935,
	author = { Ezzeldin  Hussein M  and  de Tullio  Marco D  and  Vanella  Marcos  and  Solares  Santiago D  and  Balaras  Elias },
	title = {A Strain-Based Model for Mechanical Hemolysis Based on a Coarse-Grained Red Blood Cell Model},
	year = {2015},
	journal = {ANNALS OF BIOMEDICAL ENGINEERING},
	volume = {43},
	keywords = {Computational fluid dynamics; Mechanical hemolysis; Multiscale modeling; Prosthetic heart valves; Ventricular assist devices; Biomedical Engineering},
	url = {http://link.springer.com/journal/volumesAndIssues/10439},
	doi = {10.1007/s10439-015-1273-z},	
	pages = {1398--1409}
}
@conference{
	11589_62871,
	author = { Di Renzo  M  and  Coclite  A  and  De Tullio  M D  and  De Palma  P  and  Pascazio  G },
	title = {LES of the Sandia Flame D Using an FPV Combustion Model},
	year = {2015},
	publisher = {Elsevier Ltd},
	journal = {ENERGY PROCEDIA},
	volume = {82},
	booktitle = {Energy Procedia},
	keywords = {Flamelet progress variable; Large eddy simulation; Methane-air combustion; Partialy premixed flame; Energy (all)},
	url = {http://www.sciencedirect.com/science/journal/18766102},
	doi = {10.1016/j.egypro.2015.11.824},	
	pages = {402--409}
}
@conference{
	11589_62872,
	author = { De Marinis  D  and  De Tullio  M D  and  Napolitano  M  and  Pascazio  G },
	title = {A conjugate-heat-transfer immersed-boundary method for turbine cooling},
	year = {2015},
	publisher = {Elsevier Ltd},
	journal = {ENERGY PROCEDIA},
	volume = {82},
	booktitle = {Energy Procedia},
	keywords = {Conjugate heat transfer; Immersed boundary method; Turbine cooling; URANS; Energy (all)},
	url = {http://www.sciencedirect.com/science/journal/18766102},
	doi = {10.1016/j.egypro.2015.12.025},	
	pages = {215--221}
}
@article{
	11589_921,
	author = { Doronzo  D M  and  Khalaf  E A  and  Dellino  P  and  de Tullio  M D  and  Dioguardi  F  and  Gurioli  L  and  Mele  D  and  Pascazio  G  and  Sulpizio  R },
	title = {Local impact of dust storms around a suburban building in arid and semi-arid regions: numerical simulation examples
from Dubai and Riyadh, Arabian Peninsula},
	year = {2014},
	journal = {ARABIAN JOURNAL OF GEOSCIENCES},
	volume = {8},
	abstract = {Dust storms are common in arid and semi-arid regions, e.g., the Arabian Peninsula, where undisturbed wind can either weather the rocks and transport the grains for kilometers over the landscape or even overseas, or form dunes and ripples. We used a multiphase Eulerian–Lagrangian computational fluid dynamics model to investigate the impact of dust storms in the form of density current on a 10 × 10-m building. This numerical investigation particularly applies to the suburbs of metropolis, consisting of peripheral neighborhoods of meter-scale buildings that, as suggested by our results, can strongly affect the path of the storm before impacting the Downtown. Our results of flow-building interaction on pulsating (CASE 1) versus sustained (CASE 2, reference) and long-lived (CASE 3) storm show a strong amplification of flow dynamic pressure up to a factor of about 14 in streamwise direction and a heavy grain accumulation of about 800 kg around the building. With respect to reference sustained storm, the results show a more intense pressure amplification up to about 12 for slower (CASE 4) or coarser (CASE 5) storm, but a less intense amplification up to about 3 for more dilute storm (CASE 6) in transverse direction. Maximum grain accumulation around the building is of about 4,300 kg (55 % is on building front) for coarser storm, whereas high fog in the building rear occurs for more dilute storm. These results can be useful when assessing the impact of dust storms against buildings.},
	keywords = {Arabian Peninsula; Arid and semi-arid regions; Building impact; Dust storms; Grain dispersal; Grain suspension; Pyroclastic density currents},
	doi = {10.1007/s12517-014-1730-2},	
	pages = {7359--7369}
}
@article{
	11589_1647,
	author = { de Tullio M D  and  Singh J  and  Pascazio G  and  Decuzzi P },
	title = {Predicting the size-dependent tissue accumulation of agents released from vascular targeted nanoconstructs},
	year = {2014},
	journal = {COMPUTATIONAL MECHANICS},
	volume = {53},
	abstract = {Vascular targeted nanoparticles have been developed for the delivery of therapeutic and imaging agents in cancer and cardiovascular diseases. However, at authors' knowledge, a comprehensive systematic analysis on their delivery efficiency is still missing. Here, a computational model is developed to predict the vesselwall accumulation of agents released from vascular targeted nanoconstructs. The transport problem for the released agent is solved using a finite volume scheme in terms of three governing parameters: the local wall shear rate S, ranging from 10 to 200 s-1; the wall filtration velocity Vf , varying from 10-9 to 10-7 m/s; and the agent diffusion coefficient D, ranging from 10-12 to 10 -9 m2/s. It is shown that the percentage of released agent adsorbing on the vessel walls in the vicinity of the vascular targeted nanoconstructs reduces with an increase in shear rate S, and with a decrease in filtration velocity Vf and agent diffusivity D. In particular, in tumor microvessels, characterized by lower shear rates (S = 10 s-1) and higher filtration velocities (Vf = 10-7 m/s), an agent with a diffusivity D = 10-12 m2/s (i.e. a 50nm particle) is predicted to deposit on the vessel wall up to 30 % of the total released dose. Differently, drug molecules, exhibiting a smaller size and much higher diffusion coefficient (D = 10-9 m2/s), are predicted to accumulate up to 70 %. In healthy vessels, characterized by higher S and lower Vf , the largest majority of the released agent is redistributed directly in the circulation. These data suggest that drug molecules and small nanoparticles only can be efficiently released from vascular targeted nanoconstructs towards the diseased vessel walls and tissue.},
	keywords = {Finite volume method; Nanomedicine; Nanotheranostics; Transport problem; Vascular targeting},
	doi = {10.1007/s00466-013-0963-3},	
	pages = {437--447}
}
@article{
	11589_1310,
	author = { Bruno D  and  Panarese A  and  Diomede P  and  Longo S  and  Taccogna F  and  Minelli P  and  Surzhikov S T  and  Dikaljuk A S  and  De Palma P  and  de Tullio M D },
	title = {Particle Methods for Nonequilibrium Hypersonic and Plasma Flows},
	year = {2014},
	journal = {THE OPEN PLASMA PHYSICS JOURNAL},
	volume = {7},
	pages = {88--100}
}
@conference{
	11589_18370,
	author = { DE MARINIS D  and  DE TULLIO M D  and  PASCAZIO G  and  NAPOLITANO M },
	title = {An immersed boundary method for fluid-structure interactions},
	year = {2014},
	publisher = {Politecnico di Bari},
	address = {BARI},
	booktitle = {Proceedings of Score@poliba},
	abstract = {This paper provides some  recent results obtained in the development of Immersed Boundary (IB) methods at the Politecnico di Bari: in particular, the development and testing of one such method—using a versatile Moving Least Squares approach, coupled with a very efficient solver for solving fluid-structure interaction problems in
incompressible laminar flows—will be addressed. Such a method allows one to solve complex
three-dimensional solid-fluid interaction problems within reasonable computer times.
The solver is validated versus: the free fall of a sphere within a fluid at
rest and jellyfish propulsion. Such results demonstrate the accuracy, efficiency, and versatility of the proposed  method.},
	keywords = {IB method; fluid; structure}
}
@conference{
	11589_18220,
	author = { DE MARINIS D  and  DE TULLIO M D  and  PASCAZIO G  and  NAPOLITANO M },
	title = {An Immersed boundary method for coupled multi-physics simulations},
	year = {2014},
	booktitle = {Computational Fluid Dynamics 2014}
}
@conference{
	11589_23353,
	author = { Pappalettere C  and  De Palma P  and  Pascazio G  and  De Tullio M  and  Camporeale S  and  Dambrosio L  and  Fortunato B  and  Torresi M  and  Fornarelli F  and  Carbone G  and  Afferrante L  and  Bottiglione F  and  Mantriota G  and  Foglia MM  and  Demelio G  and  Ciavarella M  and  Lamberti L  and  Boccaccio A  and  Ludovico AD  and  Csmpanelli SL  and  De Filippis LAC  and  Tricarico L  and  Palumbo G  and  Sorgente D  and  Scintilla LD  and  Galantucci LM  and  Percoco G  and  Lavecchia F  and  Casavola C  and  Naso N  and  Lino P  and  Maione G  and  Stasi S  and  Turchiano B  and  Cupertino F },
	title = {Advanced technologies for reduction of polluting emissions, fuel consumption and
operating costs of Heavy Duty engines, INNOVHEAD},
	year = {2014},
	volume = {Track A},
	booktitle = {Atti del "1st WORKSHOP on the State of the art and Challenges Of Research Efforts @ POLIBA"}
}
@conference{
	11589_16489,
	author = { Verzicco R  and  De Vita F  and  de Tullio M D },
	title = {Numerical simulation of the blood flow in the aortic root with a non-Newtonian fluid model},
	year = {2013},
	booktitle = {AIMETA 2013 Atti del XXI Congresso dell’Associazione Italiana di Meccanica Teorica e Applicata}
}
@conference{
	11589_16476,
	author = { de Tullio M.D.},
	title = {Fluid dynamics and blood damage in artificial heart valves: biological vs. mechanical aortic prostheses},
	year = {2013},
	booktitle = {AIMETA 2013 Atti del XXI Congresso dell’Associazione Italiana di Meccanica Teorica e Applicata}
}
@article{
	11589_1778,
	author = { Weltert L  and  de Tullio MD  and  Afferrante L  and  Salica A  and  Nardella S  and  Scaffa R  and  Maselli D  and  Bellisario A  and  Verzicco R  and  De Paulis R },
	title = {Annular dilatation and loss of sinotubular junction in aneurismatic aorta: implications  on leaflet quality at the time of surgery. A Finite Element study.},
	year = {2013},
	journal = {INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY},
	volume = {17},
	booktitle = {European Association for Cardio-Thoracic Surgery, EACTS Meeting, October 26-31, Barcelona, Spain},
	doi = {10.1093/icvts/ivt116},	
	pages = {1--5}
}
@article{
	11589_52117,
	author = { Stigliano C  and  Aryal S  and  de Tullio M D  and  Nicchia G P  and  Pascazio G  and  Svelto M  and  Decuzzi  and  P },
	title = {SiRNA-chitosan complexes in poly(lactic-co-glycolic acid) nanoparticles for the silencing of aquaporin-1 in cancer cells},
	year = {2013},
	journal = {MOLECULAR PHARMACEUTICS},
	volume = {10},
	abstract = {A large number of studies document the strong expression of aquaporin-1 (AQP1) in tumor microvessels and correlate this aberrant expression with higher metastatic potential and aggressiveness of the malignancy. Although small animal experiments have shown that the modulation of AQP1 expression can halt angiogenesis and induce tumor regression, effective and safe strategies for the tissue specific inhibition of AQP1 are still missing. Here, small interference RNA-chitosan complexes encapsulated in poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) are proposed for the intracellular delivery of siRNA molecules against AQP1. These NPs are coated with poly(vinyl alcohol) (PVA), to improve stability under physiological conditions, and demonstrate a diameter of 160 nm. The partial neutralization of the negatively charged siRNA molecules with the cationic chitosan enhances the loading by 5-fold, as compared to that of the free siRNA molecules, and allows one to modulate the release kinetics in the pH-dependent manner. At pH = 7.4, mimicking the conditions found in the systemic circulation, only the 40% of siRNA is released at 24 h post incubation; whereas at pH = 5.0, recreating the cell endosomal environment, all siRNA molecules are released in about 3 h. These NPs show no cytotoxicity on HeLa cells up to 72 h of incubation. In the same cells, transfected to overexpress AQP1, a silencing efficiency of 70% is achieved at 24 h post treatment with siRNA-loaded NPs. Confocal microscopy analysis of NP uptake demonstrates that siRNA molecules accumulate perinuclearly and in the nucleus. Given the stability, preferential release behavior, and well-known biocompatibility properties of PLGA nanostructures, these siRNA-loaded NPs hold potential for the efficient and safe in vivo silencing of AQPs via systemic administration.},
	keywords = {aquaporins, polymeric nanoparticles, siRNA, tumor therapy},
	doi = {10.1021/mp400224u},	
	pages = {3186--3194}
}
@article{
	11589_52329,
	author = { Cherubini S  and  de Tullio M D  and  De Palma P  and  Pascazio G },
	title = {Optimal perturbations in boundary-layer flows over rough surfaces},
	year = {2013},
	journal = {JOURNAL OF FLUIDS ENGINEERING},
	volume = {135},
	booktitle = {ASME 2012 Fluids Engineering Summer Meeting FEDSM2012
July 8–12, 2012, Puerto Rico, USA},
	abstract = {This work provides a three-dimensional energy optimization analysis, looking for perturbations inducing the largest energy growth at a finite time in a boundary-layer flow in the presence of roughness elements. The immersed boundary technique has been coupled with a Lagrangian optimization in a three-dimensional framework. Four roughness elements with different heights have been studied, inducing amplification mechanisms that bypass the asymptotical growth of Tollmien-Schlichting waves. The results show that even very small roughness elements, inducing only a weak deformation of the base flow, can strongly localize the optimal disturbance. Moreover, the highest value of the energy gain is obtained for a varicose perturbation. This result demonstrates the relevance of varicose instabilities for such a flow and shows a different behavior with respect to the secondary instability theory of boundary layer streaks.},
	doi = {10.1115/1.4025028},	
}
@article{
	11589_52352,
	author = { Cherubini S  and  de Tullio M D  and  De Palma P  and  Pascazio G },
	title = {Transient growth in the flow past a three-dimensional smooth roughness element},
	year = {2013},
	journal = {JOURNAL OF FLUID MECHANICS},
	volume = {724},
	abstract = {This work provides a global optimization analysis, looking for perturbations inducing the largest energy growth at a finite time in a boundary-layer flow in the presence of smooth three-dimensional roughness elements. Amplification mechanisms are described which can bypass the asymptotical growth of Tollmien-Schlichting waves. Smooth axisymmetric roughness elements of different height have been studied, at different Reynolds numbers. The results show that even very small roughness elements, inducing only a weak deformation of the base flow, can localize the optimal disturbance characterizing the Blasius boundary-layer flow. Moreover, for large enough bump heights and Reynolds numbers, a strong amplification mechanism has been recovered, inducing an increase of several orders of magnitude of the energy gain with respect to the Blasius case. In particular, the highest value of the energy gain is obtained for an initial varicose perturbation, differently to what found for a streaky parallel flow. Optimal varicose perturbations grow very rapidly by transporting the strong wall-normal shear of the base flow, which is localized in the wake of the bump. Such optimal disturbances are found to lead to transition for initial energies and amplitudes considerably smaller than sinuous optimal ones, inducing hairpin vortices downstream of the roughness element.},
	keywords = {boundary layer stability, boundary layers, transition to turbulence},
	doi = {10.1017/jfm.2013.177},	
	pages = {642--670}
}
@conference{
	11589_25018,
	author = { Ezzeldin H  and  de Tullio M D  and  Solares S  and  Balaras E },
	title = {Evaluation Of Hemolysis Models Using A High Fidelity Blood Model},
	year = {2012},
	booktitle = {Bulletin of the American Physical Society, 65th Annual Meeting of the APS Division of Fluid Dynamics. Volume 57, Number 17}
}
@conference{
	11589_52561,
	author = { de Tullio M D  and  Pascazio G  and  Napolitano M },
	title = {Arbitrarily Shaped Particles in Shear Flow},
	year = {2012},
	booktitle = {Seventh International Conference on Computational Fluid Dynamics (ICCFD7), Big Island, Hawaii, July 9-13, 2012}
}