@article{
	11589_62257,
	author = { Coclite  A  and  Cutrone  L  and  Gurtner  M  and  De Palma  P  and  Haidn  O J  and  Pascazio  G },
	title = {Computing supersonic non-premixed turbulent combustion by an SMLD flamelet progress variable model},
	year = {2016},
	journal = {INTERNATIONAL JOURNAL OF HYDROGEN ENERGY},
	volume = {41},
	abstract = {This paper presents a statistically more likely distribution (SMLD) approach for the evaluation of the presumed probability density function (PDF) in flamelet progress variable (FPV) models for non-premixed supersonic combustion. The numerical simulation of the NASA Langley Research Center supersonic H2-Air combustion chamber is performed using two approaches: the first one is a standard FPV model, built presuming the functional shape of the PDFs of the mixture fraction, Z, and of the progress parameter, Λ; the second approach employs the SMLD technique to presume the joint PDF of Z and Λ. The standard and FPV-SMLD models have been developed using the low Mach number assumption. In both cases, the temperature is evaluated by solving the total-energy conservation equation, providing a more suitable approach for the simulation of supersonic combustion. By comparison with experimental data, the proposed SMLD model is shown to provide a clear improvement with respect to the standard FPV model, especially in the auto-ignition and stabilization regions of the flame.},
	keywords = {Hydrogen-air combustion; Joint presumed PDF modelling; Reynolds-averaged Navier-Stokes equations; Renewable Energy, Sustainability and the Environment; Fuel Technology; Condensed Matter Physics; Energy Engineering and Power Technology},
	url = {http://www.journals.elsevier.com/international-journal-of-hydrogen-energy/},
	doi = {10.1016/j.ijhydene.2015.10.086},	
	pages = {632--646}
}
@article{
	11589_70521,
	author = { De Marinis  Dario  and  De Tullio  Marco Donato  and  Napolitano  Michele  and  Pascazio  Giuseppe },
	title = {Improving a conjugate-heat-transfer immersed-boundary method},
	year = {2016},
	journal = {INTERNATIONAL JOURNAL OF NUMERICAL METHODS FOR HEAT & FLUID FLOW},
	volume = {26},
	keywords = {Conjugate heat transfer; Immersed boundary method; URANS; Mechanical Engineering; Mechanics of Materials; Computer Science Applications1707 Computer Vision and Pattern Recognition; Applied Mathematics},
	url = {http://www.emeraldinsight.com/info/journals/hff/hff.jsp},
	doi = {10.1108/HFF-11-2015-0473},	
	pages = {1272--1288}
}
@article{
	11589_73850,
	author = { Coclite  Alessandro  and  de Tullio  Marco Donato  and  Pascazio  Giuseppe  and  Decuzzi  Paolo },
	title = {A combined Lattice Boltzmann and Immersed boundary approach for predicting the vascular transport of differently shaped particles},
	year = {2016},
	journal = {COMPUTERS & FLUIDS},
	volume = {136},
	keywords = {Immersed boundary; Lattice-Boltzmann; Neutrally buoyant particle; Particle transport; Shear flow; Computer Science (all); Engineering (all)},
	doi = {10.1016/j.compfluid.2016.06.014},	
	pages = {260--271}
}
@article{
	11589_75847,
	author = { Tuttafesta  Michele  and  Pascazio  Giuseppe  and  Colonna  Gianpiero },
	title = {Multi-GPU unsteady 2D flow simulation coupled with a state-to-state chemical kinetics},
	year = {2016},
	journal = {COMPUTER PHYSICS COMMUNICATIONS},
	volume = {207},
	keywords = {Domain decomposition; Euler equations; Flux-vector splitting scheme; GPU and multi-GPU; High enthalpy flows; State-to-state kinetics; Hardware and Architecture; Physics and Astronomy (all)},
	url = {http://www.elsevier.com/wps/find/journaldescription.cws_home/706710/description#description},
	doi = {10.1016/j.cpc.2016.07.016},	
	pages = {243--257}
}
@article{
	11589_56097,
	author = { Doronzo  Domenico M  and  de Tullio  Marco D  and  Pascazio  Giuseppe  and  Dellino  Pierfrancesco  and  Liu  Guilin },
	title = {On the interaction between shear dusty currents and buildings in vertical collapse: Theoretical aspects, experimental observations, and 3D numerical simulation},
	year = {2015},
	journal = {JOURNAL OF VOLCANOLOGY AND GEOTHERMAL RESEARCH},
	volume = {302},
	abstract = {We investigate the behavior of vertical building collapses that, at impact on the ground, can generate shear dusty currents. These currents macroscopically resemble natural currents like dust storms and pyroclastic density currents, which may heavily interact with the surroundings while propagating. In particular, shear dusty currents are generated because of building collapse after pulverization, whereas pyroclastic density currents can be generated because of eruptive column or volcano collapse after fragmentation. Pyroclastic density currents can move for kilometers, and then load the surroundings by flow dynamic pressure; a similar dynamical behavior occurs in shear dusty currents that load buildings. We employed 3D engineering fluid dynamics to simulate the generation (by vertical collapse), and the propagation and building interaction of shear dusty currents. We used an Eulerian-Lagrangian multiphase approach to model the gas-particle flow, and an immersed boundary technique to mesh the domain, in order to account for sedimentary processes and complex 3D urban geometry in the computation. Results show that the local dynamic pressure of the shear current is amplified up to a factor ~. 10 because of flow-building interaction. Also, the surroundings consisting of multiple buildings and empty spaces make walls and streets as surfaces of particle accumulation, which from the collapse zone on can get thinner by exponential law. These results can help better assessing the intricate interaction between pyroclastic density currents and urban surroundings, as well as better link fragmentation, collapse and density current to each other.},
	keywords = {Dynamic pressure; Flow-building interaction; Fragmentation; Particle accumulation; Pyroclastic density currents; Shear dusty current; Geochemistry and Petrology; Geophysics},
	url = {http://www.sciencedirect.com/science/journal/03770273},
	doi = {10.1016/j.jvolgeores.2015.07.011},	
	pages = {190--198}
}
@article{
	11589_1220,
	author = { Coclite A  and  Pascazio G  and  De Palma P  and  Cutrone L  and  Ihme M },
	title = {An SMLD Joint PDF Model for Turbulent Non-Premixed Combustion Using the Flamelet Progress-Variable Approach},
	year = {2015},
	journal = {FLOW TURBULENCE AND COMBUSTION},
	volume = {95},
	abstract = {This paper provides an improved flamelet/progress variable (FPV) model for the simulation of turbulent combustion, employing the statistically most likely distribution (SMLD) approach for the joint probability density function (PDF) of the mixture fraction, Ζ, and of the progress parameter, Λ. Steady-state FPV models are built presuming the functional shape of the joint PDF of Ζ and Λ in order to evaluate Favre-averages of thermodynamic quantities. The mixture fraction is widely assumed to behave as a passive scalar with a mono-modal behaviour modelled by a β-distribution. Moreover, under the hypothesis that Ζ and Λ are statistically independent, the joint PDF coincides with the product of the two marginal PDFs. In this work we discuss these two constitutive hypotheses. The proposed model evaluates the most probable joint distribution of Ζ and Λ, relaxing some crucial assumption on their statistical behaviour. This provides a more general model in the context of FPV approach and an effective tool to verify the adequateness of widely used hypotheses. The model is validated versus experimental data of well-known test cases, namely, the Sandia flames. The results are also compared with those obtained by the standard FPV approach, analysing the role of the PDF functional form on turbulent combustion simulations. © 2015 Springer Science+Business Media Dordrecht.},
	doi = {10.1007/s10494-015-9609-1},	
	pages = {97--119}
}
@conference{
	11589_25120,
	author = { Coclite A  and  Pascazio G  and  De Palma P },
	title = {A Flamelet Progress Variable model for compressible reacting flows},
	year = {2015},
	booktitle = {86th Annual Meeting
of the International Association
of Applied Mathematics and Mechanics, Book of Abstracts 2015},
	pages = {425--425}
}
@conference{
	11589_62871,
	author = { Di Renzo  M  and  Coclite  A  and  De Tullio  M D  and  De Palma  P  and  Pascazio  G },
	title = {LES of the Sandia Flame D Using an FPV Combustion Model},
	year = {2015},
	publisher = {Elsevier Ltd},
	journal = {ENERGY PROCEDIA},
	volume = {82},
	booktitle = {Energy Procedia},
	keywords = {Flamelet progress variable; Large eddy simulation; Methane-air combustion; Partialy premixed flame; Energy (all)},
	url = {http://www.sciencedirect.com/science/journal/18766102},
	doi = {10.1016/j.egypro.2015.11.824},	
	pages = {402--409}
}
@conference{
	11589_62872,
	author = { De Marinis  D  and  De Tullio  M D  and  Napolitano  M  and  Pascazio  G },
	title = {A conjugate-heat-transfer immersed-boundary method for turbine cooling},
	year = {2015},
	publisher = {Elsevier Ltd},
	journal = {ENERGY PROCEDIA},
	volume = {82},
	booktitle = {Energy Procedia},
	keywords = {Conjugate heat transfer; Immersed boundary method; Turbine cooling; URANS; Energy (all)},
	url = {http://www.sciencedirect.com/science/journal/18766102},
	doi = {10.1016/j.egypro.2015.12.025},	
	pages = {215--221}
}
@conference{
	11589_62873,
	author = { Torresi  Marco  and  De Tomaso  Elena  and  Fortunato  Bernardo  and  Camporeale  Sergio Mario  and  Pascazio  Giuseppe },
	title = {High frequency dynamics of force coefficients in vawt blades under dynamic stall condition},
	year = {2015},
	publisher = {American Society of Mechanical Engineers (ASME)},
	volume = {9},
	booktitle = {Proceedings of the ASME Turbo Expo},
	abstract = {Blades of lift driven Vertical Axis Wind Turbines can experience dynamic stall especially at low tip speed ratios. Dynamic stall has significant consequences in terms of performance, vibration, noise and structural integrity of the blades. For this reason, it is worth to investigate this complex phenomenon. In particular, detailed CFD analyses have been carried out on a pitching NACA 0015 airfoil performing several cycles using a RANS approach and implementing the Transition SST turbulence model in order to take into account the laminar-to-turbulent boundary layer transition. A good agreement has been achieved in terms of phase-averaged force coefficients versus angle of attack when comparing these numerical results with the experimental data obtained at Glasgow University. However, looking at the instantaneous time-dependent force coefficients over several cycles, it appears that, in particular during the blade down-stroke, the hysteresis cycles are quite different one from the other and all from the phase-averaged one. Moreover, each hysteresis cycle shows oscillations at frequencies higher than that of the pitching motion. The investigation of such a behavior can be important in order to avoid the occurrence of dangerous resonance conditions at the blade natural frequency.},
	keywords = {CFD; Dynamic stall; Pitching airfoil; Transition SST turbulence model; VAWT; Engineering (all)},
	url = {http://www.asmedl.org/journals/doc/ASMEDL-home/proc/},
	doi = {10.1115/GT2015-42987},	
}
@conference{
	11589_77099,
	author = { Coclite  A  and  Cutrone  L  and  De Palma  P  and  Pascazio  G },
	title = {Numerical investigation of high-pressure combustion in rocket engines using flamelet/progress-variable models},
	year = {2015},
	publisher = {American Institute of Aeronautics and Astronautics Inc, AIAA},
	booktitle = {53rd AIAA Aerospace Sciences Meeting},
	keywords = {Aerospace Engineering},
	doi = {10.2514/6.2015-1109},	
}
@conference{
	11589_18443,
	author = { Cutrone L  and  Tuttafesta M  and  Capitelli M  and  Schettino A  and  Pascazio G  and  Colonna G },
	title = {3D nozzle flow simulations including state-to-state kinetics calculation},
	year = {2014},
	volume = {1628},
	booktitle = {Proceedings of the 29th International Symposium on Rarefied Gas Dynamics},
	doi = {10.1063/1.4902723},	
	pages = {1154--1161}
}
@article{
	11589_921,
	author = { Doronzo  D M  and  Khalaf  E A  and  Dellino  P  and  de Tullio  M D  and  Dioguardi  F  and  Gurioli  L  and  Mele  D  and  Pascazio  G  and  Sulpizio  R },
	title = {Local impact of dust storms around a suburban building in arid and semi-arid regions: numerical simulation examples
from Dubai and Riyadh, Arabian Peninsula},
	year = {2014},
	journal = {ARABIAN JOURNAL OF GEOSCIENCES},
	volume = {8},
	abstract = {Dust storms are common in arid and semi-arid regions, e.g., the Arabian Peninsula, where undisturbed wind can either weather the rocks and transport the grains for kilometers over the landscape or even overseas, or form dunes and ripples. We used a multiphase Eulerian–Lagrangian computational fluid dynamics model to investigate the impact of dust storms in the form of density current on a 10 × 10-m building. This numerical investigation particularly applies to the suburbs of metropolis, consisting of peripheral neighborhoods of meter-scale buildings that, as suggested by our results, can strongly affect the path of the storm before impacting the Downtown. Our results of flow-building interaction on pulsating (CASE 1) versus sustained (CASE 2, reference) and long-lived (CASE 3) storm show a strong amplification of flow dynamic pressure up to a factor of about 14 in streamwise direction and a heavy grain accumulation of about 800 kg around the building. With respect to reference sustained storm, the results show a more intense pressure amplification up to about 12 for slower (CASE 4) or coarser (CASE 5) storm, but a less intense amplification up to about 3 for more dilute storm (CASE 6) in transverse direction. Maximum grain accumulation around the building is of about 4,300 kg (55 % is on building front) for coarser storm, whereas high fog in the building rear occurs for more dilute storm. These results can be useful when assessing the impact of dust storms against buildings.},
	keywords = {Arabian Peninsula; Arid and semi-arid regions; Building impact; Dust storms; Grain dispersal; Grain suspension; Pyroclastic density currents},
	doi = {10.1007/s12517-014-1730-2},	
	pages = {7359--7369}
}
@article{
	11589_1647,
	author = { de Tullio M D  and  Singh J  and  Pascazio G  and  Decuzzi P },
	title = {Predicting the size-dependent tissue accumulation of agents released from vascular targeted nanoconstructs},
	year = {2014},
	journal = {COMPUTATIONAL MECHANICS},
	volume = {53},
	abstract = {Vascular targeted nanoparticles have been developed for the delivery of therapeutic and imaging agents in cancer and cardiovascular diseases. However, at authors' knowledge, a comprehensive systematic analysis on their delivery efficiency is still missing. Here, a computational model is developed to predict the vesselwall accumulation of agents released from vascular targeted nanoconstructs. The transport problem for the released agent is solved using a finite volume scheme in terms of three governing parameters: the local wall shear rate S, ranging from 10 to 200 s-1; the wall filtration velocity Vf , varying from 10-9 to 10-7 m/s; and the agent diffusion coefficient D, ranging from 10-12 to 10 -9 m2/s. It is shown that the percentage of released agent adsorbing on the vessel walls in the vicinity of the vascular targeted nanoconstructs reduces with an increase in shear rate S, and with a decrease in filtration velocity Vf and agent diffusivity D. In particular, in tumor microvessels, characterized by lower shear rates (S = 10 s-1) and higher filtration velocities (Vf = 10-7 m/s), an agent with a diffusivity D = 10-12 m2/s (i.e. a 50nm particle) is predicted to deposit on the vessel wall up to 30 % of the total released dose. Differently, drug molecules, exhibiting a smaller size and much higher diffusion coefficient (D = 10-9 m2/s), are predicted to accumulate up to 70 %. In healthy vessels, characterized by higher S and lower Vf , the largest majority of the released agent is redistributed directly in the circulation. These data suggest that drug molecules and small nanoparticles only can be efficiently released from vascular targeted nanoconstructs towards the diseased vessel walls and tissue.},
	keywords = {Finite volume method; Nanomedicine; Nanotheranostics; Transport problem; Vascular targeting},
	doi = {10.1007/s00466-013-0963-3},	
	pages = {437--447}
}
@conference{
	11589_18370,
	author = { DE MARINIS D  and  DE TULLIO M D  and  PASCAZIO G  and  NAPOLITANO M },
	title = {An immersed boundary method for fluid-structure interactions},
	year = {2014},
	publisher = {Politecnico di Bari},
	address = {BARI},
	booktitle = {Proceedings of Score@poliba},
	abstract = {This paper provides some  recent results obtained in the development of Immersed Boundary (IB) methods at the Politecnico di Bari: in particular, the development and testing of one such method—using a versatile Moving Least Squares approach, coupled with a very efficient solver for solving fluid-structure interaction problems in
incompressible laminar flows—will be addressed. Such a method allows one to solve complex
three-dimensional solid-fluid interaction problems within reasonable computer times.
The solver is validated versus: the free fall of a sphere within a fluid at
rest and jellyfish propulsion. Such results demonstrate the accuracy, efficiency, and versatility of the proposed  method.},
	keywords = {IB method; fluid; structure}
}
@conference{
	11589_18220,
	author = { DE MARINIS D  and  DE TULLIO M D  and  PASCAZIO G  and  NAPOLITANO M },
	title = {An Immersed boundary method for coupled multi-physics simulations},
	year = {2014},
	booktitle = {Computational Fluid Dynamics 2014}
}
@conference{
	11589_23353,
	author = { Pappalettere C  and  De Palma P  and  Pascazio G  and  De Tullio M  and  Camporeale S  and  Dambrosio L  and  Fortunato B  and  Torresi M  and  Fornarelli F  and  Carbone G  and  Afferrante L  and  Bottiglione F  and  Mantriota G  and  Foglia MM  and  Demelio G  and  Ciavarella M  and  Lamberti L  and  Boccaccio A  and  Ludovico AD  and  Csmpanelli SL  and  De Filippis LAC  and  Tricarico L  and  Palumbo G  and  Sorgente D  and  Scintilla LD  and  Galantucci LM  and  Percoco G  and  Lavecchia F  and  Casavola C  and  Naso N  and  Lino P  and  Maione G  and  Stasi S  and  Turchiano B  and  Cupertino F },
	title = {Advanced technologies for reduction of polluting emissions, fuel consumption and
operating costs of Heavy Duty engines, INNOVHEAD},
	year = {2014},
	volume = {Track A},
	booktitle = {Atti del "1st WORKSHOP on the State of the art and Challenges Of Research Efforts @ POLIBA"}
}
@inbook{
	11589_52441,
	author = { Coclite A  and  Pascazio G  and  De Palma P  and  Cutrone L },
	title = {An extended SMLD approach for presumed probability density function in flamelet combustion model},
	year = {2013},
	booktitle = {XXI Congresso Associazione Italiana di Meccanica Teorica e Applicata}
}
@article{
	11589_3557,
	author = { Tuttafesta M  and  Colonna G  and  Pascazio G },
	title = {Computing unsteady compressible flows using Roe's flux-difference splitting scheme on GPUs},
	year = {2013},
	journal = {COMPUTER PHYSICS COMMUNICATIONS},
	volume = {184},
	abstract = {A Roe's flux-difference splitting scheme has been implemented using the NVIDIA CUDA architecture and has been applied to solve the two-dimensional compressible Euler equations. Different standard test cases have been considered in order to estimate the speed-up of GPU computing with respect to CPU calculation. A detailed description of the kernel configuration has been provided and a theoretical analysis of the GPU execution time as a function of the number of threads managed by the kernels is also reported. The loss of performance has been fully described consequent to the use of zero-copy memory. Significant performance improvements have been obtained by using a more recent GPU and CUDA Toolkit. A test case on multi-GPU architecture has been presented in the domain decomposition approach.},
	keywords = {2D Riemann problem, CUDA GPU computing, CUDA kernel configuration, Flux-difference splitting, Multi-GPU},
	doi = {10.1016/j.cpc.2013.01.018},	
	pages = {1497--1510}
}
@article{
	11589_52117,
	author = { Stigliano C  and  Aryal S  and  de Tullio M D  and  Nicchia G P  and  Pascazio G  and  Svelto M  and  Decuzzi  and  P },
	title = {SiRNA-chitosan complexes in poly(lactic-co-glycolic acid) nanoparticles for the silencing of aquaporin-1 in cancer cells},
	year = {2013},
	journal = {MOLECULAR PHARMACEUTICS},
	volume = {10},
	abstract = {A large number of studies document the strong expression of aquaporin-1 (AQP1) in tumor microvessels and correlate this aberrant expression with higher metastatic potential and aggressiveness of the malignancy. Although small animal experiments have shown that the modulation of AQP1 expression can halt angiogenesis and induce tumor regression, effective and safe strategies for the tissue specific inhibition of AQP1 are still missing. Here, small interference RNA-chitosan complexes encapsulated in poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) are proposed for the intracellular delivery of siRNA molecules against AQP1. These NPs are coated with poly(vinyl alcohol) (PVA), to improve stability under physiological conditions, and demonstrate a diameter of 160 nm. The partial neutralization of the negatively charged siRNA molecules with the cationic chitosan enhances the loading by 5-fold, as compared to that of the free siRNA molecules, and allows one to modulate the release kinetics in the pH-dependent manner. At pH = 7.4, mimicking the conditions found in the systemic circulation, only the 40% of siRNA is released at 24 h post incubation; whereas at pH = 5.0, recreating the cell endosomal environment, all siRNA molecules are released in about 3 h. These NPs show no cytotoxicity on HeLa cells up to 72 h of incubation. In the same cells, transfected to overexpress AQP1, a silencing efficiency of 70% is achieved at 24 h post treatment with siRNA-loaded NPs. Confocal microscopy analysis of NP uptake demonstrates that siRNA molecules accumulate perinuclearly and in the nucleus. Given the stability, preferential release behavior, and well-known biocompatibility properties of PLGA nanostructures, these siRNA-loaded NPs hold potential for the efficient and safe in vivo silencing of AQPs via systemic administration.},
	keywords = {aquaporins, polymeric nanoparticles, siRNA, tumor therapy},
	doi = {10.1021/mp400224u},	
	pages = {3186--3194}
}